Questions about the technology
The personalized recipe comes from a genetic test. We find out which nutrients a person needs and which nutrients the person cannot use due to genetic problems. A detailed training about this topic can be found here.
The main point of the product is to remain healthy. So one effect this broiled has is that it reduces the risk of developing diseases, this person has a genetic risk for. So in many cases it cannot be felt or measured after one month. We do know that these micronutrients work, because the recipe is based on numerous genetic studies, at found out that certain micronutrients reduce the risk or the severity of certain diseases.
To ensure bioavailability we have created the micro-transporters:
1. If you take vitamins see as a powder, 50% of it is removed from your body after 30 minutes. Another 50% after another 30 minutes and so on. To ensure continuous availability of vitamins C, the body needs to receive this vitamin on a slow and continuous basis. This is why our micro-transporters release the vitamins over 12 hours.
2. Some substances block each other in uptake such as calcium and zinc. This is why these substances are not in micro-transporters together. One micro-transporter releases small amounts of calcium in one position of the intestine and another micro-transporter releases sink in another position so they do not block each other.
3. 80% of vitamins and minerals used in NutriMe are of biological sources, which improves bioavailability.
Here is a more detailed explanation of the advantages of the micro-transporter technology.
Actually, there is a so called “upper tolerable limit” for virtually any commonly taken vitamin and mineral. The European Food Safety Agency (EFSA) releases scientific reviews on the tolerable upper limit at which (even when taken daily over long periods of time) no adverse reactions occur. There are also tolerable upper intake (UL) limits for water soluble vitamins that must be considered.
We are aware of the tolerable upper limits and we stay below (often far below) these limits in the supplement dosages.
Vitamin C: UL = 2000mg/day –––– Maximum Dose = 260mg
Vitamin B6: UL = 25mg –––– Maximum Dose = 4mg
Vitamin B12: UL = 1000µg –––– Maximum Dose = 10µg
Calcium: UL = 2500mg –––– Maximum Dose = 1800mg
But some UL are in fact a lot lower as is the case for magnesium. Here the UL is 350mg, so a product/supplement should never go higher than this. Note, that there are supplements on the market, that contain up to 720mg! So also for water soluble compounds, the tolerable upper level must be considered.
The supplements also contain the vitamins A, D3 and E which are all fat-soluble vitamins. Normally fat-soluble vitamins should not be taken daily because, rather than passing straight through the body, the body stores any excess in the liver and fat tissue when not used. Is that true?
Here are also tolerable upper levels known:
Vitamin E: UL = 300mg –––– maximum dose = 60mg
Vitamin A: UL = 6000µg –––– maximum dose = 2500µg
Vitamin D3: UL = 50µg –––– maximum dose = 25µg
But you are right, this is an important issue to consider, as some supplements go up to 500µg per day. Therefore, by staying well below the limit where it becomes unhealthy for the individual to take it on a daily lifelong basis, we ensure adequate supply (especially when the need is higher) and prevent overdosing of the substance. In case you want to dive deeper into the UL Aspect, here is the review about Vitamin E by the EFSA:
I am concerned that if the pure supplements are taken daily, there will indeed be a gradual build up of these fat-soluble vitamins in the body. This can be toxic and lead to health problems. Are the research scientists not concerned about the build-up of these vitamins in the body, and if not, why not?
As we stay well below the limits of what is considered to be the upper tolerable long term intake limit, which even allows for a diet rich in these supplements, unhealthy buildup is prevented.
Correct. The upper limit of daily intake is 50µg. The normal intake recommended is (depending on who you ask) between 5 and 20µg. The NHS actually recommends 10µg. The problem is, that Vitamin D3 has been shown to be preventive in some situations at 25µg, which is 2.5 times higher than the NHS’s recommendation for everyone and still only half of what is considered to be the upper safe limit to take daily. As a consequence, we dose Vitamin D3 from normal amounts (5-10µg for normal people) to the amounts proven to be effective in scientific studies (25µg for those genetic profiles that need higher amounts). We are hence in the effective range without coming close to the intake levels that could be considered a health risk with long term intake.
An intake above 6000µg on a long term basis is a health risk. Our maximum dose goes to 2500µg, which is less than half of what would be considered a health risk. Vitamin A: UL = 6000µg –––– maximum dose = 2500µg
The misconception is, that if everyone gets the normal recommended amount of vitamins, that they are perfectly supplied with this vitamin. From genetics we learn, that people’s needs are highly variable. Vitamin E is a powerful antioxidant, that protects especially cell walls from free radicals. These consist of fatty layers, making a fat soluble vitamin a good protective agent.
Most people have good protection against free radicals because their genes recognize and neutralize them. Important genes for this are SOD2, GPX1, GSTT1, GSTP1, GSTM1 and NQO1. If these work well, the body is protected and normal amounts of antioxidants suffice. This is what medicine and nutrition currently considers the average and normal state and so all recommendations are made with the assumption that these genes work correctly in everyone. The reality is, that many people have genetic errors in these genes, which reduces their protection. Their genetics and normal amounts of vitamins are not sufficient to award sufficient protection. In these cases we go higher in the daily amounts to counteract the missing genetic protection.
1) 20% of the population have a genetic variation in the LCT gene associated with lactose intolerance. This leads them to ingest 280 mg less calcium per day. We counteract this by giving 280 mg more, so that their intake is the same as that of other people without this genetic variation.
2) People with normal amounts of selenium and functioning GPX1 genes are protected from certain free radicals. GPX1 is a so called „selenoprotein“ and needs selenium to be built. If a person has a certain genetic variation/error in the GPX1 gene, the function is reduced. Normal amounts of selenium would then lead to lower GPX1 activity and free radical protection. Also, the selenium loss form the body is higher in these individuals. Science has shown, that increasing the selenium amount in carriers one GPX1- gene variation carriers can restore the GPX1 function loss and counteract the increased selenium loss. So this is what we do. In the end 2 different people with 2 different genetic profiles are given 2 different amounts of selenium to then have the same GPX1 activity and protection from free radicals.
So wisdom before we learned about genetics was that if everyone gets the RDA amount of each vitamin and mineral, we are optimally supplied with nutrients. The reality is that for some people this is sufficient and for some people this represents a metabolic deficiency.
We advice the supplement as an add-on to a nutritional change not as a replacement. The program comes with a list of food types that should be increased (lots of beneficial vitamins and minerals) or should be avoided (fewer nutrients and more negative substances). The supplements come as an add on to ensure you definitely get the required amount even when you don’t follow the diet correctly or if the nutrient content in the food is too low.
As such we attempt to change everything about nutrition. A blood test gives you a good overview of the status quo. But are there any deficiencies that need to be tackled? The “Problem” is that knowing the status quo would not influence the recommendations, as these deficiencies would be solved by the new nutrition and if not by that, by the supplements. As a consequence doing a blood test before, might be interesting, but not very medically relevant. What can be done is a blood test 1-2 months later. We have the ability to then change the recipe based on the results to better fine tune what actually arrives in the bloodstream. The problem is, that vitamin measurements in blood are quite expensive. Doing the whole panel costs in the range of €320. We do a lot of these experiments (blood tests correlated with supplements) in our lab, but the take home message is, that most if not all people react to the supplements in the intended way.
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