General questions and answers
This is an important point, which is often not considered. Some gene defects are so rare that a genetic test simply cannot be justified. One example is the hereditary fructose intolerance. About one in 20,000 people have a defect in the relevant gene, which means that only one in twenty thousandth tests makes sense. These tests bring profit to their vendors, even if they have no practical application. Our genetic tests were compiled taking into account this fact. The frequency of each genetic defect for which the Novogenia laboratory offer analyses can be found on the product page.
Genetic tests are a complex issue and therefore you should make sure that detailed advice is available and that you will find out all the important information about the genetic test. The interpretation of the results can be complicated under certain circumstances, and you should have the opportunity to ask an expert. For this reason, our genetic tests can be carried out only under expert advice of our partners or your family doctor. Additionally, easy to understand reports and detailed advice videos are at your disposal. Please contact us and we will recommend one of our partners.
Few people can use a statement like "You are homozygous for a risk allele of the Factor V Leiden mutation". So make sure that the result is prepared in plain language, to save you frustration. You can get a first impression of how our final reports look like under "Demo”.
Many genetic test providers focus on the detection of disease-causing gene defects and the scope of services usually ends at this point. Make sure that you get a prevention program in the event of an increased disease risk, which helps prevent the disease. This aspect is strongly emphasized in our finished genetic analysis reports.
Be wary of genetic testing which test for diseases for which there are no effective preventive or treatment measures. In this case, the knowledge of a genetic risk is a mental load which cannot be countered with preventive measures. Although this knowledge could be of interest for some people, the benefits are very limited. DNA Plus has no such genetic testing in the program and only offers genetic testing that can also yeld preventive measures.
Many genetic tests are sold as "novelty" or “just for fun” tests – which means they must not align to the strict regulations (quality assurance, etc.) of the medical genetic tests. These genetic tests are typically not monitored by doctors and should in no way provide a basis for health measures. Our genetic analyzes are a medical service that operates only under the highest quality standards and is subject to, among other, certification bodies monitored by the Austrian Federal Ministry of Health.
Some genes have not yet been sufficiently scientifically validated to allow a clear confirmation on the relationship between a gene and a disease. Therefore, we consider for our program only those genes that have been frequently identified as risk genes in large scientific studies.
Make sure that your preventive measures are compiled and monitored by doctors. Only in this way you can also ensure that you receive medically accurate information for prevention. Genosense collaborates with leading doctors and scientists in order to provide preventive measures of the highest medical standards.
Data security is an important aspect in this area. Ensure that data security measures are observed and that no one else has access to your analytical results. At Genosense, we meet severe data protection measures to ensure the highest security for your data. Convince yourself; you can find more information under "Security".
Our tests can generally not be ordered over the internet as we see a full and competent support as indispensable for the performance of the genetic analysis. Therefore, we work with partners who professionally support you in the performance of the analysis. Just send us an e-mail with your adress and we will send you the contact details of our partners nearby.
There are a number of mechanisms that defang free radicals and are controlled by genes.
The SOD2 gene for example neutralizes the free radical superoxide in the mitochondria.
The GPX1 gene neutralizes free radicals in other tissue.
The GST* enzyme in the liver neutralizes other free radicals in other tissue.
There are also possibilites to measure oxidative stress. Each one has benefits and disadvantages.
1. One measures the free radicals directly in the blood or urine.
- The problem is that the oxidative stress problems in the cells are not recognized and measured.
2. One measures the damage the free radicals cause.
- Here also, the picture is incomplete depending on where it is measured.
3. One measures the antioxidative enzymes (which are created by the genes).
- A very indirect possibility.
Depending on which test was conducted the picture will vary because there are just too many different kinds of oxidative stress.
Oxidative stress can be triggered by various factors:
5. Competitive sports
7. Bad diet
But also without these risk factors through a missing genetic protection:
8. Genetic variation
We analyze the genetic variations and therefore know whether the body has a basic protection against oxidative stress or not. If not we modify the environment and diet to compensate the missing protection. When the genes are fine and there is nevertheless increased stress it probably means that an additional risk factor increases the oxidative stress, so the genes cannot fight against it.
The genetic analyses of Genosense are only performed through a saliva probe. Suitable swabs can be found in our provided probe sets. Unfortunately, we cannot analyse any other kind of human probes.
The genetic results are communicated in the form of a book. It comprises of up to 200 pages and includes all important findings of the genetic analysis written in a comprehensible language. If desired by the customer the personal genetic report can also be downloaded via the security server as a PDF document or be shipped for a low surcharge in the form of a printed book to the customer.
The unique selling proposition of Genosense is the clear and understandable processing of the genetic results. All reports are written in understandable language and are therefore comprehensible for everybody. Additionally to the results practical tips for a provision are given.
The genetic analysis can be cancelled any time and you have at all times the right to change your decision and have the analysis results destroyed by us. The revoking of the contract is possible for up to 7 days after the income of the probe.
As the quality of the DNA has a massive influence on the duration of the analysis a collection should be performed carefully. We recommend a collection directly after getting up in the morning, before dental hygienes and liquid intake.
Included in the price is the shipment of the probe package and the personalized final report. The end product is the extensive report with the analysis results and the relevant action recommendations and/or provisional program of the laboratory. This report is valid for a lifetime. Please contact our customer support for more information
The sample for the analysis will be taken from the saliva. A cotton swab is used to sweep over the inside of the cheeks to collect cells of the oral mucosa. They contain all genes of a human being. The sample will be brought into the laboratory in Salzburg. There, we will extract the DNA from the saliva, which will be mixed with the appropriate agents, and the necessary gene variations will be analyzed in an automated laboratory process. The analysis technology uses the microfluids process and the fluidigm chemistry. The scientific interpretations of the data will be done by DNA Plus (itself managing director and owner) in Germany, Freilassing. The result will be confirmed by two different scientists and released for the printing of the booklet. The analysis report is sent to a doctor, supervisor or the client depending on the form of the analysis.
The managing director is Dr. of Biotechnology and Bachelor of Micro Biology. The laboratory manager has a master`s in genetics, and all laboratory personnel including the laboratory manager has years of experience in human genetics. The laboratory works according to the compelling requirements of the Austrian gene technology commission, and is licensed and audited by Austria. Furthermore, we work under the voluntary ISO 15189 quality management system and are certified accordingly. Novogenia is the European market leader in its area.
This depends on the analysis. According to the wish, from one to 200 different gene variations are analyzed. These gene variations were scientifically linked to the development of certain diseases or the reaction to certain nutrition. The respective gene variations will be analyzed and personalized recommendations will be issued on the basis of the genetic profile.
From one to 200 depending on the program. For the weight reduction, eight genes are analyzed, and for the nutrigenetic, the diet according to the genes, it`s 52.
The company was founded in 2009 to close a gap in the health system: diseases caused by gene defects will be diagnosed early and prevented. Almost every one of the widespread common diseases has a strong genetical basis, and although the sciences has been aware of this for years lacked in the application of this knowledge. Besides the preventive gene analysis, new programs, like weight reduction and nutrigenetic, the diet according to the genes, developed. Every year, 1 million new scientific publications are published and every year the ones about the genetics doubles compared to the previous year. For this reason, new, better and more precise possibilities are available to read information from one`s own genes and to use them respectively.
In the field of the preventive and lifestyle diagnostic, Genosense is the European market leader. Genosense Diagnostics also belongs to the pioneers in the preventive genetical diagnostic. The preventive and lifestyle panel tests the worldwide biggest amount of medical and lifestyle relevant genetical variations. The number of sample is strongly dependent on the season and varies between 5000 and 8000 samples per month with a double digit yearly growth throughout the last years.
No. Your genes remain unchanged from your birth to the end of your life, therefore it makes no sense to test the same gene several times, because you would only get back the same result. This also means that your innate disease risk will remain the same your whole life. However, genes influence your health, and you can significantly reduce your individual risk of illness with preventive measures.
This is a legitimate question, and in some genetic tests we think that it makes no sense to know the risk, if you cannot influence the apparition of the disease by preventive measures. Finding out that you carry such a genetic defect has no benefit for health, and it is merely a psychological burden. That is why our program includes only those genes that, while significantly increasing a potential risk of disease, also allow for preventive measures which may prevent the outbreak or aggravation the disease. Only submit to those tests that make sense from the prevention point of view and can bring real benefits for your health.
It makes no sense to test genetic defects for which the precautionary measures are limited to "Stop smoking and have a healthy diet!", because this advice applies to each and every individual. Therefore, our genetic tests focus on diseases for which preventive measures exceed the general health advices and include measures that are specific to the prevention of particular diseases. A good example is the iron storage disease, wherein, among other things, regular blood donations can prevent the increase of iron concentration in the body, and thus often this fatal disease. This is a simple and effective preventive measure, one only needs to know about his personal risk and the precautionary steps he needs to take.
Some genes are rarely defective and therefore lead to an increased risk of disease only for very few cases. The fructose gene is a good example because it is defective only in one of 20,000 people, leading to fructose intolerance. Offering this genetic test to the masses would not make sense, since so very few people could be helped. Therefore, our genetic tests focus exclusively on genes that are often defective, in order to help as many people as possible. An example is testing for lactose intolerance, which affects every 4th-6th European.
According to the current state of scientific knowledge, it is not yet possible or allowed to interfere with the genes of a human being and to correct defects. Currently, all we can unfortunately do is to identify the genetic defects, and to determine the precautionary measures that mitigate or neutralize the effects of the defect.
No. Every person carries about 2,000 genetic defects that adversely affect their health. To have genetic defects is therefore quite common, and almost every person is genetically predisposed to some diseases. After genetic testing, you will also receive an effective prevention program that helps to prevent the disease. The knowledge of a genetic risk helps you protect yourself against the disease and prevent you from triggering it by ignorance and a wrong lifestyle. Your doctor or the partner with whom you perform the genetic testing will accompany you through the entire process in an advisory capacity.
Our laboratory has more than 3000 different genetic analyses, so the answer is very varied. The most popular programs, the weight reduction and the genetically healthy diet have information like:
• Do you gain weight because of a too high percentage of fat in the foot, or are you resistant to this?
• Do you gain weight because of a too high percentage of carbon hydrate in the foot, or are you resistant to this?
• How effective is sport or a reduction of calories to lose weight?
• How much sport and what kind of sport should you do to lose weight the most effectively?
• Which of more than 900 kinds of food are no problem for the weight and which should be avoided?
• Which nutrition does the body need more and which are especially unhealthy for the body?
• After the consideration of more than 40 ingredients, more than 900 kinds of food will be rated for the personal health potential.
• Which of the normally positive ingredients of food (for example omega 3 fatty acids) are really negative for a person?
• Which micro nutrients should a person take in which doses to counter health risks or to support the own genetical strengths?
• Furthermore, there are 40 genetically personalized main dishes or up to 100 genetically adapted recipes to reduce weight or to just keep it constant.
Again, a short answer on a very varied topic: a study (Robertaille 2003) conducted an interesting experiment: more than 700 people have eaten more fat and calories for a long period of time. No surprise was that some of them gained weight. What was really interesting was that some of them were resistant (did not gain weight). Today we know (through replication studies) why. Genes control how much fat we take out of the food. Does the body have enough, the rest remains in the intestines and so remains unabsorbed. The people who do not gain weight because of more fat in the foot have this genetical protection. The people who gain weight with this have variations in their genes that disturb this function. It is similar with carbon hydrates. We can find out: is fat in the food a cause for overweight? If the answer is no, you can eat more fat but have to reduce the carbon hydrates. Thereby, you eat what does NOT cause overweight and less of the food that is problematic. With the gene analysis, we find out what is more effective: sport or less food? And we do more of that what works better. Thereby, as everyone does what is more effective for him the diet is more effective as well. In our own study, we compared the effectivity of a general nutrition consultation and our program. The result was a 2.4-fold higher rate of weight loss.