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NutriMe Complete

NutriMe Complete - Micronutrients based on the genes

Chapter 6
Micronutrients based on the genes

Training video

Spoken text of the video

Section 1: Intro

Chapter 6. NutriMe Complete. This is a training about personalized micronutrients based on your genetic profile. This is an add-on product. If you have not seen the training for the DNANutriControl Package, please do watch that before, especially the one for the nutrition sensor, because the nutrition sensor tests more than fifty genes to find out certain aspects of your body. We need this information in order to be able to create this personalized supplement. So please do watch this training before. In the layout of the different supplements, you will find it here. It is below the nutrition sensor and it is available for three months, six months, twelve months as well as long-term subscriptions. Just to summarize it.

Here we look at many different genetic variants that increase your risk for certain diseases or certain metabolic problems. Just quickly to summarize it again. We look at bone health, anything to do with osteoporosis, calcium, vitamin D, magnesium. Eye health, macular degeneration. Heart health, cholesterol, homocysteine and all of these blood levels. Food intolerances such as gluten and lactose intolerances. Joint health where the immune system is too aggressive and attacks joints. Metabolism health, hemochromatosis, which is the balance of how much iron your body stores. Mental health that is Alzheimer’s disease, antioxidants and detoxification of heavy metals and toxic substances. All of these areas are covered by NutriMe Complete.

We make sure that we get the right balance of nutrients to balance out any deficiencies that a person might genetically have in these areas. Let me give you few examples. There is incredibly too much science behind this. This is just supposed to give you an overview of how it works with a few good examples. So, I am going to talk you through these examples.



Section 2: Micronutrients examples

An example of micronutrients needed in higher doses for some people based on genetics is the GPX1 gene. It produces the GPX1 enzyme. This enzyme is unable to work unless it gets selenium; selenium is a trace element in food. This selenium is integrated and then this enzyme is active. It can recognize free radicals and neutralize them. Free radicals, as I explained in other trainings, are toxic chemicals that are produced by metabolism and they start damaging things unless they are recognized by enzymes or antioxidants and neutralized. As long as the GPX1 gene is functional and you have selenium, you are protected from certain type of free radicals.

In people that have selenium deficiencies or too little selenium, we know that not enough of these enzymes is activated, so they only have maybe thirty percent activity and you lack protection. This is why a selenium deficiency or part of it is unhealthy. If you increase the amount of selenium to the normal amount, more of it is activated and you have a higher protection that is why having enough selenium is important. So far so good. This is why you need selenium. There is, however, a genetic variation in this gene that changes the blueprint of this enzyme. It is built in a slightly different way. This leads to the enzyme still accepting selenium and recognizing free radicals, but the function of this enzyme is much weaker, let us say in this example fifty percent less.

What happens is even with normal amounts of selenium, with a genetic variation, you have a low activity, because the mutation of this genetic variation is just interrupting the function. What is very interesting is that scientists have found that if you then increase the amount of selenium, not to the normal amount, but to far above the normal amount, you can rescue some of the functions. You can increase the amount of activity again. This here is the gene, the GPX1 gene. If you do not know what this type of table means, please do watch the simple disease risk statistics training which will really explain it to you. I will quickly go through it with you again. This is the gene, this is what it does, the three different genetic result possibilities. It just means every person has two copies of this gene, one from the father, one from the mother, and we just look at one genetic variation of this gene, there is where people differ. Having a C here on both genes would mean that both genes work; you have a good protection from free radicals. Having a T here means that both of them are kind of broken or inhibited, therefore, you have less protection or you can have a G and a T. These are the three different possibilities and this is how common they are; sixty seven percent of people around you of the general population have a C C and seven percent have a T T.

This here is the science behind it. In case you are a scientist, and you are interested, you can check out these scientific publications that have shown these effects. So, what is the logic that we do with supplement doses? We check out the GPX1 gene. We know it is functional, then you need the normal recommended daily allowance of selenium and so you are protected. Then, if you have a genetic variation, we know your enzymes work less well. We know that we need a higher dose to reach the same effect. We would go far above the recommended daily allowance and increase the amount to make sure that you still get protection for your cells.

This is a very important aspect because some people say why do a genetic test? Why not do a blood test and measure how much selenium is in this person’s blood and then if it is too little, increase the amount. The problem is this is not really a personalized approach, because you would expect that this is the normal range of selenium in blood, so here is zero, this is the normal range. A person with a blood test would say if you are down here, you need more, if you are up here you need less, because this is the good range. They assume that for everybody the same range applies. That is the problem. That is exactly what we see here because some people need the normal range, that is the one on the left side, and others should be far above because of the genetic variation. Really, we cannot normalize everybody to the same amount of selenium, but you need to check out the genetics behind it to find out what the requirement is. You cannot do this from a blood test but from a test of genes. Here we have seen that a genetic variation modifies how much of one substance I need; I might need more, I might need less.



Section 3: Coenzyme Q10

Then, an example of how a micronutrient might have no effect at all. This is coenzyme Q10. This substance is something that is found in a lot of beauty creams because beauty creams try to fight ageing. Coenzyme Q10 might have more effect when it is swallowed. However, there is a gene which produces an enzyme that modifies Q10 into ubiquinol. Ubiquinol is a very strong antioxidant, which means it grabs onto free radicals and neutralizes them. Free radicals are part of the reasons for ageing that is why coenzyme Q10 is in beauty creams to combat free radicals because it is converted.

Alright. This here is a gene and if we look at it, sixty-six percent have functional enzymes, thirty percent have only one of the two is functional and four percent do not have functioning enzymes. Therefore, what happens is the following: this gene is completely non-functional, Q10 is swallowed, or comes in through a skin cream, and then it has no function. It cannot neutralize free radicals. This also means four percent of all women that are taking coenzyme Q10 supplements, maybe for half of their life, and it is also a very expensive supplement, have done it completely for nothing because their body could not convert it. More importantly, the protection they were hoping to get from it is extremely lacking because the body also produces the enzyme Q10 and it also cannot convert this.

So, what can you do if through a genetic test you know that this gene is defective? For one thing, you can use ubiquinol. You do not have to swallow Q10 but the already activated ubiquinol to combat free radicals. This is one approach. An alternative approach is to use other antioxidants in higher amounts so they can also grab onto free radicals. Really, Q10 is a good idea for some people. It is not functional for others and then you might need other substances in higher amounts to counteract the missing effect through this missing gene. Then, the logic again is if NQO1 is working, it produces the enzyme, we use Q10 as an antioxidant. If it is mutated, Q10 is not going to work, we use ubiquinol or any of the other antioxidants to protect us. It is a different approach, different nutrients needed to achieve the same thing based on genetic differences. Alright. We have seen that some people need more of something than others due to genetics. We have also seen that some people do not react to one thing. They need something else due to genetics. These two aspects have already been explained.



Section 4: Factor one: Lactose intolerance

Here, let us look at calcium requirement, because what people think about calcium is healthy bones. It is true, but it is only a very small part of the many roles that calcium has in our body. The amount of calcium that we should take, the recommended daily allowance that some institutions have determined, is eight hundred milligrams for everybody. Now, let us look at the genetic differences in calcium requirement. Factor one, lactose intolerance. A lactose tolerant person can eat milk products. It means they have a genetic variation so that the digestive system of milk sugar is not switched off with age. So, they are lactose tolerant. They tend to eat more milk products. They generally tend to eat more calcium through their diet. If the recommended daily allowance as determined is eight hundred milligrams, this person through his nutrition can eat six hundred milligrams and he would be lacking two hundred milligrams per day to reach the amount that institutions have deemed as the right amount.

A lactose tolerant person with a genetic variant should eat two hundred milligrams of calcium to reach the optimum amount. Then, there is a genetic variation that makes people lactose intolerant. It means they cannot digest milk products and they tend to avoid them. Scientific studies have shown that people who are lactose intolerant digest significantly less calcium. They are going to need a lot more calcium to reach the recommended amount. Again, the tendency of a genetic variant that causes you to be lactose intolerant has an effect on how much calcium you need to reach your optimum amount. That was the first factor of lactose intolerance. We test you genes. We found out you have the tendency of being a lactose intolerant. We increase the amount of calcium, while for other people we do not need to.



Section 5: Factor two: Osteoporosis

The second factor, osteoporosis. Healthy bones as I have said. The general concept is that bone density increases with age, up to the age of twenty five, thirty and then it starts to decrease again. This is completely normal. Probably it has something to do with the Stone Age. The general life span we had in the Stone Age was around age thirty, so it increases until the age thirty and then we die of some other reasons. Now, we are living three times that age, so bone density starts to decrease again with age, which is completely normal.

However, some people have a genetic variation that speeds up this effect. So, older people first get osteopenia, weaker bones, and eventually osteoporosis, where bones can break with a minor impact and so on. The important thing is that preventing osteoporosis is very effective and virtually it is the only effective thing because lost bone mass is usually lost forever. It is hard, if not impossible, to increase bone mass again. So, you want to reduce the loss rather than be left with the problem of not being able to get it back. The European Food Safety Agency says that the recommended daily allowance is eight hundred milligrams.

There are also some scientific studies that have looked at older people and gave them one thousand and two hundred milligrams of calcium per day. Then, they looked at these people five years later and checked, the ones they got calcium, how much their bone mineral density decreased compared to other people who got meat. They really found that if you get this amount of calcium, one thousand and two hundred milligrams, as a supplement, you have protection for your bones than if you do not. So, we know from scientific studies that one thousand and two hundred milligrams would be a nice number.

However, the European Food Safety Agency says that with eight hundred milligrams, there is a discrepancy. Therefore, what we do is we test your genetic risk for osteoporosis. If your risk is low, the normal risk, the normal amount is going to be sufficient again; the eight hundred milligrams. However, if we know you have six-fold higher risk of developing osteoporosis, the normal amount will not apply to you because the risk is not normal. It is much higher. So, what we would do then is we go for the amounts that we know from studies are effective. In this case, depending on your risk, you will have a higher dosage or a lower dosage, depending on your genetics. Ok, this is lactose intolerance, osteoporosis. The next question is detoxification of heavy metals.



Section 6: Detoxification

There is a genetic test that we do, through which we can find out phase two of detoxification that removes heavy metals. Lead is one of these heavy metals, which is very toxic to the human body. Thankfully, we have a number of genes that protect us from this. They produce enzymes that recognize lead, modify it enzymatically, neutralize it, and remove it from the body. If this toxic substance gets into our body, it is neutralized. It is removed by the kidneys. However, as you can guess, if you have a genetic variation, errors in these genes, these do not function and lead is not neutralized. This can then cause lead poisoning; it can cause cancer and can be very unhealthy for your body.

Now, scientific studies have shown that calcium has the ability to bind lead. If you have low levels of lead that are continuously increasing, because of the detoxification system, then calcium can bind lead and then neutralize it through your body. I have to say that this does not mean that if you have a cute lead poisoning, taking a calcium supplement would solve the problem. Calcium only binds lead very weakly. So, if you have a cute poisoning, you need a chelation therapy by doctors of this. This is not a replacement for this. However, if you know that you have a bad detoxification of lead, you can use calcium to keep the levels in check. More calcium would be beneficial if you have bad lead detoxification. So, now we have seen three factors. Let me tell you, there are many more that influence calcium, but just these three factors are influenced by genetics.

So, how can we find the right dose? Just as a simplified system, the recommended daily allowance would be eight hundred milligrams. If the person has no lactose intolerance, no osteoporosis risk and no limited detoxification and everything else is in order, this person would be recommended the normal recommended daily allowance. However, if the person is lactose intolerant, then we would have to compensate for the less calcium he takes in food. Therefore, we will add a little bit of calcium. Then, osteoporosis is not a problem and limited detoxification as well, so we will add a little calcium as well. So, this person would eat more calcium because of some genetic problems. Another genetic problem would need another dose and if all of the genes say we need a lot of calcium, it would be the full dose that we know from scientific studies is going to be effective. Alright. This is the general concept. We look at a lot of different aspects, we combine them together and then we decide how much calcium this person really needs.



Section 7: HDL Cholesterol

Then, an example of how a micronutrient can have a different effect. One effect on one person and a different effect on another person. This sounds a very interesting story. A common situation that happens is a person with low HDL cholesterol; that is good cholesterol. A person talks to a doctor and the doctor says yes we need to fix this. I would recommend using omega-3 supplements.

These are the fish oil capsules. Fish oil contains omega-3. This latter tends to improve HDL cholesterol level. So, taking the supplement tends to be inefficient. However, it is controversial, because some studies have shown this is absolutely the case. Other studies have shown this is not so convincing. It really tends to be different from study to study. So, some people are questioning if this is really the case, because if another person would come to this doctor and the doctor says yes you have low HDL cholesterol, I just had a patient that worked well for him, you should do the same. This person takes omega-3 supplements and suddenly HDL cholesterol becomes worse. So, the same substance is improving HDL cholesterol in one person and makes it worse in the other. Actually, from my genetic test I know that I am here. So, for me HDL cholesterol is getting worse from taking omega-3 fatty acid, but it is getting better for other people. And the question is why? That is genetic variation. The APOA1 gene.

Scientists have found AA genome types improve HDL cholesterol with omega-3 and for GG genome types, which are what I have, it becomes worse. So, people with the AA genome type can be recommended to use omega-3 to improve cholesterol and people with GG genome type should not take omega-3 supplements but they should use phytosterols. This is a kind of an alternative to omega-3, which also improves cholesterol. In that case, cholesterol improves as well. So, you can achieve the same thing with different substances but one substance might be good for one person and bad for another person. That is also something that people do not consider. This is really the big difference in nutrigenetics, why are people so unique and different? Now, what dosage of omega-3 fatty acid is optimal? The recommended daily allowance would be two hundred and fifty milligrams, which is based on studies. The ones that we have seen to be effective is one thousand and two thousand nine hundred milligrams.

Again, the EFSA, the European Food Safety Agency says two hundred and fifty milligrams is optimal for everybody. We know from one study it is one thousand five hundred, and from another study, it is one thousand milligrams and from another study, it is two thousand nine hundred milligrams. We have seen that all these are beneficial amounts. So, what we do is if you do not have any increased risk, any increased amount, you would get the normal amount and if we know that you really do need more omega3, we would go in the range which studies have shown to be effective. So, looking at HDL cholesterol, omega-3, is a simplified kind of logic.

First, we check the genes that would make your HDL cholesterol worse. If they are ok, we know that you do not have a predisposition to bad HDL cholesterol. That is ok. Then, the next question is we check the APOA1 gene. Is omega-3 good for your HDL cholesterol? If yes, then you would get the normal amount of omega-3. So far so good. If, however, we know the genes are ok but omega-3 is going to make cholesterol worse, then we would not use omega3 but phytosterols as an alternative to improve cholesterol, but only very small amounts. However, if we know that the genes are not ok, but predispose you to very bad HDL cholesterol levels, then the next question is “is omega-3 good?”. If yes, we give you a lot of omega-3 to combat the effect of this gene. If the APOA1 says omega-3 is bad, then we would not use omega-3 but large amounts of phytosterols. So, really by looking at these different genes and different pathways we achieve the same thing. There are many genes that are playing into it and substances that react differently. It is a lot complicated to know the reasons behind these things. This is the general concept. I have given you few examples.



Section 8: Personalized pellets

These are about ten different genes and we are testing more than fifty genes that have an influence on a number of different aspects of your body. The aim of this product is to take all of this into account. In mine in here, if I have a high risk of Alzheimer’s disease, then I have many antioxidants in here and if I have omega-3 fatty acids that make my cholesterol worse, then I do not have omega-3 fatty acids in here.

However, some people have more calcium, others do not. This is highly personalized. To give you an idea. When we analyze twenty or more than fifty genes, we can dose more than twenty different micronutrients based on your genes; more for you, less for someone else. We have more than seven hundred trillion different recipe options. This is how unique your genetic profile is. This is about how many possible different options there are. You will have your name on here. This is produced specifically for one person with your name on here. You see the bars in here, they say how much of each substance is in here. Each nutrient mixture is unique unless you are mono-psychotic twins, which would mean they have the same genes, the same age, the same sex. Those would really get the same product. All of the others will have a different product. Here is actually where you see the bars. How much of each of the substances you have.

So, another question is that since we know how much calcium, how much vitamin C, E, D and so on, how can we follow these requirements? Standard products are really going to make it difficult for you. You might find that one has the right amount of vitamin c, if you take two and a half pills, but you will have too much of the other thing, and you might have omega-3 in it which you do not want and so on. You are not going to find a standard product that is going to cover your needs. Personalized mixed gelatin capsules have no drawbacks. For one thing, they are very expensive to produce and for the other there are different substances that fight against each other to be taken up like calcium and zinc. If you mix them together as powders, it is only going to be calcium that is taken up and zinc is blocked by calcium and it is not taken up.

Therefore, mixing powders together in capsules is not also a good solution. What we have is a microtransporter technology. We have, as you can see here, many small little pellets. I do not know whether you can see them in the video, there are many different colored types of pellets. Each one of them contains one vitamin. So, one for vitamin C, a different one for vitamin E, one for vitamin A and so on. We find out what your requirements are. For me, it is many antioxidants, so I get lots of vitamin C and lots of vitamin E. All of these are mixed together in different concentrations. Then, I have this spoon, just to show you. For me it is just eight milliliters of pellets. For someone else, it is five and so on. So, it really differs. This pellet is what I should ingest. These pellets also has another advantage. They are slow release especially in the case of vitamin C. Vitamin C has a half-life of thirty minutes. Meaning if I swallow one hundred milligrams of vitamin c and I absorb it into my blood stream, half an hour later I got fifty, half an hour later twenty five milligrams, half an hour later twelve milligrams.

So, vitamin C is broken down very quickly. Slow-release pellets have the advantage that they contain vitamin C and then they release it to your body gradually, overall across eight hours. Your body continuously receives vitamin C even though it is broken down quickly. It is continuously supplied with more. Actually, talking about vitamin C, there is a very interesting story. Mammals, any animals that drink milk have babies and we are part of mammals. Virtually all mammals can produce vitamin C themselves.

The only exception are humans and monkeys. The interesting fact about this is that when we look at our genome, we would have a vitamin C-producing gene. However, it has been mutated. It is broken. It is no longer functional. On the other hand, mice have the same gene, but it works. It produces vitamin C for them, so they do not need to eat it through diet. It is thought that our ancestors, you know human apes, used to be normal mammals, then they became tree-dwelling apes, and there they had a lot of vitamin C all around them. So, they ate food which was full of vitamin C and suddenly they were no longer dependent on producing their own vitamin C because they got it all day long. This is what usually happens in ageing. Something that is not required can mutate because genetic mutations happen, they disable a gene and if it is no disadvantage to the organism, it has lost its function, then it is lost, because its offspring will also have lost it and eventually they all have lost it.

So, we no longer need vitamin C gene, because our monkey ancestors got vitamin C through diet and then the climate has changed. They came down from the tree and started running around into the Savanah. They started using tools, catching animals, and they just changed the diet all the time. Suddenly, they did not have all the vitamin C anymore that their ancestors have. This now led them to be chronically deficient in vitamin C because now they just lack the enzyme that would produce it for them. This is why monkeys and humans have the problem of not producing their own vitamin C and are reliant on getting enough through their nutrition, while mice and cows and so on can all produce their own vitamin C. Ok, back to the extra topic.

Then, we have slow-release pellets that gradually give vitamin C to your body. The other advantage are these blocking agents as I have explained. When calcium and zinc are mixed together, they are going to block each other in absorption. The advantage here is that one pellet is going to contain calcium, while the other one contains zinc. Then calcium is here in the intestine and releases calcium, which is absorbed. Zinc is here, it releases zinc. Therefore, they do not block each other. So, their availability is increased. The recommendation for taking this. I take it in the mornings, so I just take the spoon for which amount it is. I personally put it in my mouth, drink it with water, it is tasteless; you should not bite on them because some of the vitamins have a bad taste. You just swallow it and then you are done with it. Other people that I know would mix it with yoghurt. Since they are slow-release, they do not dissolve so quickly, but you should not wait for them to dissolve. As it is a mesh up of different substances. it would not taste so nice. I would not take it in the evenings. It contains some vitamin C. For me it is quite a lot. Some people would react. It causes invigoration. Some people cannot sleep because it stimulates them when they take a lot of vitamin C.

So, I personally could not take it in the evening because it gives me trouble sleeping, but it is great to wake up in the morning with vitamin C and other vitamins. Therefore, I recommend taking it once per day, in the mornings or at lunchtime. Of course, you can try it in the evening. If it is not a problem, it is fine; otherwise, I would not take it in the evenings.

Section 9: End

That is the end of chapter number six. NutriMe Complete, which is personalized micronutrients based on your genetics. It is unique as your own genetic profile. This is supposed to support your nutrigenetic test in helping you make sure that you get the right amounts of the right substances (end).


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