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Inflammatory joint diseases and genetics
Spoken text of the video
Section 1: Intro
Chapter 52, inflammatory joint diseases and genetics. This is a specific training for rheumatoid arthritis, specifically the Joint Sensor genetic test. You will find this test here in our portfolio. As you can see here, it is meant for prevention and treatment. It does not give you any specific benefits in early detection or early diagnosis. So, it is really for people who want to prevent the disease from developing, but it is also useful for people who have already the disease.
Section 2: The concept
Let us now look at the concept of Inflammatory joint diseases. This here is maybe a joint of a finger. You have two bones and a cartilage, a sort of lubrication in-between. What happens in inflammatory joint diseases is that it is usually the immune system which attacks the cartilage. So, for some reason the immune system thinks the cartilage is a bacterial infection and starts fighting it. Then, this cartilage is broken down progressively until in very severe cases the bones can actually rub against each other. This causes deformation of the joints, obviously inflicting pain, and a loss of function of these joints. This is what rheumatoid arthritis is about. The aggressiveness of this immune system is modulated by genes. These are some of the genes. For example, the TNF-α gene. Just for you to know, this table is cut out from the report. You will find this information in the report. If you do not know what this table means, please do watch the simple disease risk statistics training which will explain everything about it.
Here, you can see how common the genetic variations are. 2 % have the A/A genotype. This is a 7.29 % risk of developing rheumatoid arthritis, 7 times higher risk. For the interleukin 6 gene, the C/C genotype has no risk and others have 1.36 risk but also 7 fold risk of degenerative disc disease. This is the science behind it. This X here means this is the result for this one person. In case you are interested, you can look into it. It is usually too technical for patients. I would just show it to them in this form. You have this bar. This is the normal risk, the best genetic variation. You can go all the way to here with very high risk. Again, this table will be explained to you in the simple disease risk statistics. So, here we find out you have a low or a very high risk. If it is a very high risk, it is very important for you to follow these recommendations. At lower risk, it is less important. Also, it is the same for the degenerative disc disease. This is independent of the risk of rheumatoid arthritis. This person has a very low risk.
Section 3: Prevention
Then, there is prevention. Depending on your genetic risk, we would recommend other things, which will be more important for you if you have a higher risk and less important for you if you have a very low risk of developing the disease. This is very simple to understand. Look into the report and read through it once, so you know what kind of things we are recommending. I am just summarizing it.
For one thing, as prevention you should practice sports that do not challenge the joints. Sports like swimming and less of weight lifting where you really challenge the joints. It is better to do exercises early in the morning than late in the evening. By doing this, like exercise, you will actually keep your joints active and you will protect them. Then, nutrition is a very big important aspect because there are certain substances in food, like arachidonic acid, especially in animal food, that cause inflammation. They are kind of batteries for inflammatory processes. So, if you eat lots of arachidonic acid, you will make the immune system more aggressive and you will speed up or cause these problems of joints being attacked by the immune system.
Then, omega-3 fatty acids have been shown to reduce the aggressiveness of the immune system. By taking fish oil capsules, for example, you reduce the aggressiveness and you slow the progression or you reduce the likelihood of the disease from developing. Another more important thing is that omega-3 fatty acids might be negative for your HDL cholesterol. If you have not heard about this before, do watch the cardiovascular sensor training. There is explained that depending on genetics for some people omega-3 fatty acids make HDL cholesterol worse or better. In the cardiovascular sensor, you might not be recommended to take omega-3 fatty acids because it is bad for cholesterol, but you might be recommended to take it for the joints disease. This is a problem, because it might be bad for one disease but good for another. So, it must be decided if you have a very low risk of HDL cholesterol problems and a high risk of inflammatory joint disease, I would recommend it because of the beneficial effects in this area where it is more important. Otherwise, if you have a very big problem with HDL cholesterol and virtually no risk in inflammatory joint diseases, I would not recommend it if it is negative. Really, we need to take everything into account.
Then, unsaturated fatty acids are to be preferred and omega-3, as I said, is anti-inflammatory. So, nutrition will be adapted. This is part of the Nutrition Sensor. If you have a high risk, the nutrition sensor will really help you choose foods which contain lower amounts of the bad substances and large amounts of the good substances that improve your immune system.
Section 4: Early detection
It is important for early detection to get immediate treatment. The recommendations are to consult your doctor as soon as you identify the symptoms which are morning stiffness in hand or fingers, circulatory disorders in fingers, some fingers remain colder for example, and back pain. Especially if you have a higher risk, you should look out for these symptoms and then talk to your doctor as I said to get the right treatment in time. One aspect that I would like to mention is please do watch the Pharmaco genetics test training because there you find out how certain drugs are metabolized by the body, how some drugs might not have any effect. Some might be required at lower dosages because the body cannot clear them fast enough. In this respect, this is also an important part of this test, we do find out which drugs work better or might not work at all in individuals.
So, we test a certain recommended or necessary pharmaco genetics genes. Then, we find out the common drugs that are used. This one should be used at half the dosage because the body clears it too slow. This drug should not be used at all because it is not broken down by the body and this drug might be safe to use. So, what we can really do here is find out the risk, we change the nutrition to help either prevent it or manage it when it has already occurred. When it has occurred, we also give you guidance on what drugs are more effective and which are less effective. As I said, please do watch the pharmaco genetics training to learn more about how we can improve medical treatment for such things.
This is the end of chapter 52, inflammatory joint diseases and genetics.